Factors that influence asphalt mixtures fatigue properties contain load term, environment term and the material kind.This paper studied intermittent time, frequency, temperature, aggregates gradation, asphalt species, asphalt dosage, actually which factors or which a few factors were important, how each factor influenced asphalt mixtures fatigue properties.Firstly, factors were assembled properly.Under different condition, asphalt mixtures were experimented with the fatigue tests of control stress mode using MTS810.Secondly, relation degree between each factor and fatigue life was analyzed.According to the importance of each factor, the sequence (from important to unimportant) is intermittent time→temperature→asphalt penetration index→frequency→aggregates gradation→asphalt dosage.